How does Ezetimibe work in the body?

Ezetimibe works by inhibiting the absorption of cholesterol at the intestinal brush border. This is a critical mechanism because it specifically targets the site where cholesterol is absorbed from the diet in the intestine. By blocking this absorption, Ezetimibe effectively lowers the amount of cholesterol that enters the bloodstream, which can lead to decreased LDL cholesterol levels and contribute to the management of cholesterol-related disorders.

Ezetimibe is particularly useful when used in conjunction with statins or other lipid-lowering therapies, enhancing their overall cholesterol-lowering effects. The focus on the intestinal absorption of cholesterol distinguishes it from other cholesterol-lowering agents, making Ezetimibe a unique and effective tool in the treatment of hyperlipidemia.