How should an extended-release tablet of Isosorbide Mononitrate be taken?

Isosorbide Mononitrate, particularly in its extended-release formulation, is designed to release the medication gradually over an extended period. For this reason, it is crucial that the tablet is swallowed whole without breaking, chewing, or crushing it.

Chewing or crushing the tablet can disrupt the extended-release mechanism, potentially leading to a rapid release of the drug, which may increase the risk of side effects and reduce therapeutic effectiveness. Taking the tablet as directed ensures that the medication is absorbed at the intended rate, providing effective management of conditions such as angina or heart failure over a sustained duration.

Therefore, swallowing the extended-release tablet whole is essential to maintaining its intended pharmacokinetic properties and ensuring the safest and most effective use of Isosorbide Mononitrate.