In which medical situations is Warfarin primarily indicated?

Warfarin is primarily indicated in conditions requiring anticoagulation to prevent thromboembolic events. Specifically, it plays a critical role in managing atrial fibrillation, a condition where the heart's rhythm is irregular and can lead to the formation of blood clots in the heart. These clots can dislodge and lead to a stroke if they travel to the brain. Warfarin helps reduce the risk of such complications by inhibiting vitamin K-dependent coagulation factors, thereby reducing the ability of the blood to clot.

Warfarin is also used in managing patients who have experienced a previous embolism or venous thromboembolism, ensuring that they do not develop new clots. The choice to use Warfarin in these scenarios is based on its efficacy in lowering the probability of life-threatening events related to abnormal clot formation, making it essential for patients with specific cardiovascular conditions.

The other options do not involve indications for Warfarin, as they pertain to completely different medical issues that do not require anticoagulant therapy.