What adverse effects are indicated in the box warning for Ciprofloxacin?

Ciprofloxacin, a fluoroquinolone antibiotic, carries a box warning primarily due to the serious risks associated with its use. The adverse effects mentioned in the box warning specifically highlight the potential for tendon rupture and peripheral neuropathy.

Tendon rupture is particularly concerning for patients over a certain age and those on concurrent corticosteroids, as it often affects the Achilles tendon and can lead to severe, long-term disability. Peripheral neuropathy, which can manifest as pain, burning, tingling, or numbness in the extremities, represents another serious risk that can occur with fluoroquinolone use. These effects are critical for clinicians to be aware of, as they can significantly impact the patient's quality of life and may result in permanent damage.

In contrast, while allergic reactions, respiratory depression, and hepatotoxicity are important adverse effects associated with various medications, they are not highlighted as specifically significant in the box warning for ciprofloxacin. Such nuanced understanding is essential for safe prescribing practices.