What caution should patients take regarding grapefruit juice when using Nifedipine?

Patients taking Nifedipine should avoid grapefruit juice because it can significantly interact with the medication, leading to increased levels of the drug in the bloodstream. Grapefruit juice contains compounds that inhibit cytochrome P450 3A4 enzymes in the liver, which are responsible for metabolizing many medications, including Nifedipine. When the metabolism of Nifedipine is inhibited, it can result in excessively high concentrations of the drug, potentially leading to an increased risk of side effects such as hypotension, dizziness, or heart palpitations. For this reason, it is advisable for patients to refrain from consuming grapefruit juice while on Nifedipine to ensure safe and effective treatment outcomes.