What combination therapy includes Hydrochlorothiazide?

The correct answer is that Hydrochlorothiazide, a thiazide diuretic, is commonly used in combination therapy with an ACE inhibitor. This combination is effective in managing hypertension and heart failure because the thiazide diuretic helps to control fluid retention and lower blood pressure, while the ACE inhibitor works to relax blood vessels and decrease arterial pressure. Both classes of medications complement each other, enhancing antihypertensive efficacy and providing a synergistic effect in managing cardiovascular conditions.

Thiazide diuretics are often favored in combination therapies because they can help mitigate some of the adverse effects of other antihypertensives, such as ACE inhibitors, by reducing the risks associated with fluid overload and improving overall blood pressure outcomes. Thus, these combinations are frequently recommended in treatment guidelines for hypertension management.