What common adverse drug reaction is associated with Nitroglycerin?

Nitroglycerin is a medication commonly used for the management of angina pectoris, and one of the most notable adverse drug reactions associated with its use is headache. This occurs because nitroglycerin, a vasodilator, causes the blood vessels to relax and expand, which can lead to increased blood flow to the brain and trigger headache.

Headaches are particularly common during the initial dosing or when the dosage is increased, and although they typically diminish with continued use, they can be quite bothersome for patients. The mechanism behind this side effect is largely related to its effects on nitric oxide release and the subsequent vasodilation. Understanding this helps healthcare providers prepare patients for potential side effects, improving adherence to the medication regimen.

While nausea, dizziness, and chest pain can also occur as side effects, they are not as frequently reported or directly linked to nitroglycerin as headache. Recognizing headache as a common adverse event is important for patient education and management of expectations regarding the drug's side effects.