What condition can abrupt discontinuation of Verapamil Hydrochloride precipitate?

Study for the 2PD Top 200 Drugs Anti-Infectives and Cardiovascular Agents Test. Access flashcards and multiple choice questions, each with hints and explanations. Get ready for your exam!

Abrupt discontinuation of Verapamil Hydrochloride can lead to hypertensive rebound or crisis due to its role as a calcium channel blocker and antihypertensive agent. When taken regularly, Verapamil helps to control blood pressure and manage conditions like hypertension and certain types of arrhythmias. It works by relaxing the blood vessels, thereby lowering the heart's workload.

If Verapamil is suddenly stopped, the body may experience a rapid increase in blood pressure, often exceeding pre-treatment levels. This rebound effect occurs because the body's compensatory mechanisms have adjusted to the presence of the medication; once removed, the arteries may constrict or the heart rate could increase, leading to a potentially dangerous situation known as hypertensive crisis. This can manifest as severe headaches, visual problems, chest pain, and even organ damage if not treated promptly.

The other conditions listed, while serious, are not directly associated with the sudden withdrawal of Verapamil. Cardiac arrest typically relates to severe arrhythmias or other acute cardiac issues not directly caused by stopping Verapamil. Pulmonary embolism and hypoglycemia are also not relevant consequences of discontinuing this medication.

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