What effect does Enalapril Maleate have on the sympathetic nervous system?

Enalapril Maleate is an ACE (Angiotensin-Converting Enzyme) inhibitor primarily used to manage high blood pressure and heart failure. It works by blocking the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. By inhibiting this pathway, Enalapril decreases the levels of angiotensin II, leading to vasodilation and reduced blood pressure.

The sympathetic nervous system is primarily involved in the "fight or flight" response, and its activation can lead to increased heart rate and blood pressure. When Enalapril inhibits the renin-angiotensin-aldosterone system (RAAS), it results in a decrease in sympathetic outflow. This inhibition leads to a reduction in sympathetic tone, which helps to further lower blood pressure and decrease cardiac workload. Therefore, the correct answer indicates that Enalapril has an inhibitory effect on the sympathetic nervous system.

This effect is beneficial in treating conditions like hypertension and heart failure, where excessive sympathetic stimulation can worsen outcomes. By dampening sympathetic activity, Enalapril contributes to overall cardiovascular stability and improvement.