What effect does Pravastatin Sodium have on LDL receptors?

Pravastatin Sodium, a member of the statin class of medications, primarily works by inhibiting the enzyme HMG-CoA reductase, which plays a crucial role in cholesterol synthesis in the liver. One of the key outcomes of this inhibition is the effect on LDL receptors.

When cholesterol synthesis is reduced, the liver cells respond by increasing the expression of LDL receptors on their surface. This increase in LDL receptors enhances the liver's ability to uptake LDL cholesterol from the bloodstream, leading to lower levels of LDL cholesterol in circulation. Therefore, the correct answer is that Pravastatin Sodium increases the binding of LDL receptors to LDL-cholesterol, facilitating its removal from the bloodstream.

This mechanism is central to the lipid-lowering effects of statins, as it not only helps in decreasing LDL levels but also contributes to overall cardiovascular health by reducing the risk of atherosclerosis and related conditions.