What is a common adverse drug reaction associated with Doxycycline?

Doxycycline, a member of the tetracycline class of antibiotics, is often linked to esophageal injury as a common adverse drug reaction. This drug can cause irritation and ulceration of the esophagus, particularly if it is not taken with sufficient water or if the patient spends time lying down shortly after ingestion. To minimize this risk, it is recommended that patients drink a full glass of water with the pill and remain upright for a period after administration.

While other adverse reactions can occur with Doxycycline, such as hepatotoxicity or allergic reactions, esophageal injury is specifically noted due to the mechanism of the drug and its administration guidelines. This highlights the importance of proper patient education regarding medication intake to prevent gastrointestinal complications.