What is a common adverse drug reaction associated with Hydrochlorothiazide?

Hydrochlorothiazide is a thiazide diuretic commonly used to treat high blood pressure and edema. One of the notable adverse drug reactions associated with Hydrochlorothiazide is headache. This can occur due to the drug's effects on electrolyte balance and fluid status, which can alter vascular tone and potentially lead to headaches.

Headaches may arise from changes in blood volume and pressure regulation caused by the diuretic properties of Hydrochlorothiazide. When patients experience fluid and electrolyte imbalances, it can lead to headaches as well as other symptoms.

The other options such as nausea, cough, and rash can occur with various medications but are not as directly tied to the pharmacological actions of Hydrochlorothiazide as headaches are. Therefore, when evaluating the common adverse effects specifically related to this medication, headache stands out as a significant and often reported reaction.