What is a common adverse drug reaction associated with Hydrochlorothiazide and Lisinopril?

The common adverse drug reaction associated with Hydrochlorothiazide and Lisinopril is hypotension and dizziness. Both medications have effects on blood pressure regulation. Hydrochlorothiazide is a thiazide diuretic that helps reduce blood pressure by promoting excretion of sodium and water, leading to a decrease in blood volume. Lisinopril, an ACE inhibitor, also lowers blood pressure by preventing the conversion of angiotensin I to angiotensin II, which causes blood vessels to relax and improve blood flow.

When these medications are used together, there is an enhanced hypotensive effect, which can lead to dizziness, especially when patients change positions quickly or are dehydrated. It's important for patients on these medications to be monitored for signs of excessive blood pressure reduction, which could lead to falls or other complications.

While nausea and vomiting, hyperkalemia, and rash can occur with various medications, they are not typical or common reactions specifically associated with the combination of Hydrochlorothiazide and Lisinopril. Hyperkalemia is more likely related to Lisinopril use alone rather than in combination with Hydrochlorothiazide, which excretes potassium. Rash can occur with many medications but is not a primary concern for