What is a common adverse drug reaction of Irbesartan?

Irbesartan is an angiotensin II receptor blocker (ARB) primarily used to manage high blood pressure and treat kidney disease associated with type 2 diabetes. One of the notable adverse drug reactions associated with this medication is hyperkalemia, which is an elevated level of potassium in the blood.

Irbesartan works by blocking the effects of angiotensin II, a hormone that can cause blood vessels to constrict and sodium retention, thereby increasing blood pressure. When this hormone's action is inhibited, there is generally less sodium retention and increased potassium levels. As a result, patients taking Irbesartan may experience hyperkalemia, particularly if they have preexisting conditions that affect potassium levels or are taking other medications that also raise potassium.

This response highlights the importance of monitoring potassium levels in patients on Irbesartan, especially those with renal impairment or those taking potassium-sparing diuretics or supplements. Understanding hyperkalemia as a potential adverse effect is crucial for proper patient management and ensuring medication safety.