What is a common adverse drug reaction associated with Ketoconazole?

Ketoconazole is an antifungal medication that can be used topically or systemically. When used in foam form for the treatment of certain skin conditions, a common adverse drug reaction associated with it is an application site reaction. This can include irritation, burning, itching, or redness at the site where the foam is applied.

The other options, while they may occur with various medications, are not specifically well-documented or as closely related to the use of Ketoconazole, particularly in its foam formulation. Headaches and nausea can occur with many medications but are not characteristic of Ketoconazole use. Chills are also not a commonly reported adverse reaction for this medication. Therefore, the application site reaction with foam is the most relevant adverse drug reaction for Ketoconazole in this context.