What is a common adverse drug reaction associated with Diltiazem Hydrochloride?

Diltiazem Hydrochloride, a calcium channel blocker commonly used to treat hypertension and angina, often leads to the adverse effect of edema. This occurs because calcium channel blockers can lead to vasodilation, which may result in fluid accumulation in peripheral tissues. While edema is a notable reaction, it is important to recognize that it can vary in severity among patients.

Other side effects listed, such as nausea, dry mouth, and constipation, may occur but are less prominently associated with Diltiazem compared to edema. Nausea might be experienced by some patients, but it is not as characteristic of Diltiazem's side effect profile. Dry mouth is usually noted with certain other medications, particularly anticholinergics, and constipation can occur with various pharmacological agents but isn't the primary concern with Diltiazem. Overall, the association of edema specifically highlights a significant class effect seen with one of the primary uses of Diltiazem in managing cardiovascular conditions.