What is a drug exposure that should be avoided when using Mupirocin?

Mupirocin is an antibiotic ointment commonly used to treat skin infections, particularly those caused by Staphylococcus aureus and Streptococcus pyogenes. It is important to avoid using Mupirocin on open wounds due to the risk of introducing the medication directly into the bloodstream, which could lead to systemic absorption and potential side effects. Additionally, applying it to open wounds may not only be less effective but can also irritate the site and hinder the natural healing process, as the medication’s mechanism relies on localized antimicrobial activity.

Using Mupirocin on moist areas of skin, dry skin, or scabbed skin is typically acceptable because these surfaces can help the medication remain localized and act effectively against the pathogens present without posing the same risks as open wounds.