What is a potential risk of abruptly discontinuing Nebivolol?

Abruptly discontinuing Nebivolol, a beta-blocker used primarily for treating hypertension and heart failure, can lead to rebound angina. This condition occurs due to a rapid increase in heart rate and myocardial oxygen demand after the cessation of the medication. When Nebivolol is stopped suddenly, the body can respond with an overactivity of the sympathetic nervous system, which can exacerbate underlying heart conditions, particularly in patients with coronary artery disease, leading to angina or even more severe cardiovascular events.

Nebivolol works by reducing heart rate and contractility, thereby decreasing myocardial oxygen consumption. Stopping it suddenly removes this beneficial effect and can lead to severe complications, especially in patients who have pre-existing heart conditions. This is why it's often recommended to taper the dosage under clinical supervision rather than stopping abruptly to avoid such risks.