What is a significant box warning associated with Levofloxacin?

Levofloxacin is a fluoroquinolone antibiotic known for its effectiveness against a variety of bacterial infections. A significant box warning associated with levofloxacin highlights the risk of tendon inflammation and rupture, particularly of the Achilles tendon. This risk is particularly heightened in certain populations, such as older adults, those taking corticosteroids, and patients with renal insufficiency. The box warning serves to emphasize the serious nature of this side effect, urging healthcare providers and patients to be vigilant about symptoms like pain, swelling, or inflammation in the tendons during treatment.

In contrast, other options do not represent the primary concerns that have been highlighted specifically for levofloxacin. While liver failure, severe allergic reactions, and cardiovascular effects can be serious issues with various medications, they are not uniquely emphasized as a primary concern in the context of levofloxacin use, making the warning about tendon issues particularly critical to recognize and remember when prescribing and taking this medication.