What is a significant warning associated with Nifedipine?

Nifedipine is a calcium channel blocker primarily used for conditions like hypertension and angina. A significant warning associated with Nifedipine is the potential for rebound hypertension, particularly when the medication is abruptly discontinued. This phenomenon occurs because Nifedipine relaxes the blood vessels and lowers blood pressure; if taken away suddenly, the body may react with a surge in blood pressure as it tries to regain equilibrium. This is especially important for patients who have been on the medication for a long time, as they may experience more severe fluctuations in blood pressure if they stop taking it suddenly.

It is crucial for healthcare providers and patients to be aware of this risk and to manage any changes in medication dosage or discontinuation under physician supervision to minimize the risk of rebound hypertension.