What is a significant warning associated with Ramipril?

Ramipril, an ACE inhibitor commonly used to treat hypertension and heart failure, has a significant warning regarding its use during pregnancy. ACE inhibitors like Ramipril can cause serious harm to the developing fetus, especially in the second and third trimesters. The medication can lead to decreased amniotic fluid and other complications, including fetal renal dysfunction and even neonatal death. This is why it is classified as a Category D medication during pregnancy, indicating evidence of risk.

Healthcare providers typically advise against using Ramipril in pregnant women and recommend exploring alternative treatments for managing hypertension that are safer during pregnancy. This makes the warning about pregnancy a critical consideration when prescribing or taking Ramipril.