What is an additional mechanism of action for Lisinopril besides being an ACE inhibitor?

Lisinopril is primarily known as an ACE (Angiotensin-Converting Enzyme) inhibitor, which helps lower blood pressure by preventing the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. One additional mechanism by which Lisinopril exerts its effects is by reducing serum aldosterone levels.

Aldosterone is a hormone produced by the adrenal glands that promotes sodium and water retention, leading to increased blood volume and higher blood pressure. By inhibiting the production of angiotensin II, Lisinopril not only relaxes blood vessels but also lowers the secretion of aldosterone. This effect contributes to the diuretic action of the drug, promoting the excretion of sodium and water, and ultimately aiding in the management of hypertension and heart failure.

The other options do not accurately represent additional actions of Lisinopril. For instance, while it does influence renal blood flow as a result of its vasodilatory effects, this is not recognized as a primary mechanism. Inhibition of platelet aggregation is more characteristic of certain other cardiovascular medications, particularly antiplatelet agents. Lastly, Lisinopril does not increase heart rate; rather, it often works to lower blood pressure,