What is the pregnancy category for Hydrochlorothiazide and Lisinopril?

Hydrochlorothiazide and Lisinopril do not have a standard pregnancy category designation because they are both classified as Category D for use during pregnancy when considering potential risks versus benefits.

Hydrochlorothiazide is not recommended during pregnancy, especially in the first trimester, as it can cause decreased placental perfusion and may affect the fetus. Lisinopril, an ACE inhibitor, is contraindicated during pregnancy due to its potential to cause fetal harm, particularly during the second and third trimesters.

None of the official categories (A, B, C) are applicable to these medications in this context. Instead, the designation of "None" reflects the fact that healthcare providers should avoid using these medications in pregnant patients due to their associated risks, thereby aligning with the understanding of these drugs' safety profiles during pregnancy.