What is the primary mechanism of action for Ramipril?

Ramipril is primarily classified as an ACE (Angiotensin-Converting Enzyme) inhibitor, which means that its main mechanism of action involves the inhibition of the ACE enzyme. This enzyme plays a critical role in the renin-angiotensin-aldosterone system (RAAS), which regulates blood pressure and fluid balance in the body.

By competitively inhibiting ACE, Ramipril prevents the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. This results in vasodilation (widening of blood vessels), reduced blood pressure, and decreased workload on the heart. Additionally, by lowering levels of angiotensin II, Ramipril also helps to decrease the secretion of aldosterone, leading to reduced sodium and water retention, further contributing to its antihypertensive effects.

Understanding ACE inhibitors like Ramipril is essential when discussing medications used to manage hypertension and certain types of heart failure, as they are integral to cardiovascular pharmacotherapy.