What is the prodrug form of Ramipril?

The prodrug form of Ramipril is Ramiprilat. Ramipril itself is an ACE inhibitor that is administered in an inactive form. Once ingested, it undergoes conversion in the liver to its active form, Ramiprilat. This metabolic transformation is crucial because Ramiprilat exerts the pharmacological effects associated with the inhibition of the angiotensin-converting enzyme (ACE), which is key in managing conditions such as hypertension and heart failure.

In the context of this question, the other medications listed serve different functions or are prodrugs of other active compounds. For example, Enalapril is itself a prodrug that converts to Enalaprilat, while Lisinopril and Quinapril are also ACE inhibitors but do not represent the prodrug form of Ramipril. Thus, understanding that Ramipril must convert to Ramiprilat to be effective highlights the significance of prodrugs in pharmacotherapy.