What should patients avoid while using Clonidine?

Patients should avoid alcohol and CNS depressants while using Clonidine because this medication primarily acts as an alpha-2 adrenergic agonist, which decreases sympathetic outflow from the central nervous system. The use of Clonidine can lead to sedation and lower blood pressure. When combined with alcohol or other central nervous system depressants, there is an increased risk of enhanced sedation and possible respiratory depression, leading to adverse effects.

While excessive exercise, high-fiber foods, and over-the-counter medications may all have their considerations during Clonidine therapy, they do not pose the same immediate risk of compounding the effects of the medication in terms of sedation or lowering blood pressure. Thus, the primary concern when taking Clonidine involves interactions that could intensify its sedative effects, making the avoidance of alcohol and CNS depressants particularly crucial.