What should patients be advised to do when taking sublingual Nitroglycerin tablets?

When taking sublingual Nitroglycerin tablets, patients should be advised to place the tablet under the tongue and let it dissolve. This method allows the medication to be absorbed quickly into the bloodstream through the mucous membranes in the mouth. Sublingual administration bypasses the digestive system and the first-pass metabolism by the liver, resulting in a more rapid onset of action, which is crucial for alleviating angina symptoms.

This dosing method leverages the unique pharmacokinetics of Nitroglycerin, effectively delivering the medication right where it's needed, and affording quicker relief from chest pain than other forms of administration would provide. It’s important for patients to understand this process to ensure they receive the maximum therapeutic benefit from their medication.