What should patients be aware of concerning the discontinuation of Losartan therapy?

When discontinuing Losartan therapy, patients should be particularly aware of the risk of rebound hypertension. Losartan is an angiotensin II receptor blocker (ARB) commonly used to treat high blood pressure, and suddenly stopping the medication can cause a significant rise in blood pressure due to the reactivation of the body's renin-angiotensin system. This rebound phenomenon can lead to even higher blood pressure levels than those experienced prior to starting the medication, potentially increasing the risk of cardiovascular events.

It is important for patients to understand that any changes to their medication regimen, especially with antihypertensive drugs like Losartan, should be done under the guidance of a healthcare provider. Typically, a gradual tapering off, rather than an abrupt discontinuation, may be recommended to minimize potential side effects, including rebound hypertension.