What should patients taking doses of rivaroxaban ≥15 mg do?

Patients taking doses of rivaroxaban at 15 mg or higher should take the medication with food. This recommendation is critical because the absorption of rivaroxaban is significantly increased when taken with food, which leads to improved efficacy of the medication. When rivaroxaban is consumed with food, it enhances its bioavailability, ensuring that the appropriate amount of the drug is absorbed into the bloodstream for its anticoagulant effect.

Taking rivaroxaban without food could result in lower levels of the medication in the body, potentially reducing its therapeutic effect and increasing the risk of thrombotic events. Therefore, adhering to the guideline of taking rivaroxaban with food ensures optimal absorption and effectiveness for patients prescribed this anticoagulant at higher doses.