What therapeutic classification does Hydrochlorothiazide and Lisinopril belong to?

Hydrochlorothiazide is classified as a thiazide diuretic, while Lisinopril is classified as an ACE inhibitor. Together, they are often used in combination for the treatment of hypertension and heart failure. The thiazide diuretic works by inhibiting sodium reabsorption in the distal convoluted tubule of the kidney, leading to increased urine output and a reduction in blood volume. This helps lower blood pressure. Lisinopril, on the other hand, blocks the conversion of angiotensin I to angiotensin II, promoting vasodilation and further reducing blood pressure.

The combination of these two medications can produce a synergistic effect on blood pressure reduction, making them more effective than either drug alone. This therapeutic classification reflects their combined use in clinical practice, which is common for managing conditions that involve excess fluid retention and high blood pressure.

The other answer options do not correctly describe the combination of Hydrochlorothiazide and Lisinopril, as neither is a beta-blocker, calcium channel blocker, or loop diuretic. Thus, the classification as a thiazide diuretic and ACE inhibitor combination accurately captures the therapeutic effects of both medications in treating hypertension.