What therapeutic classification does Sildenafil belong to?

Sildenafil is classified as a phosphodiesterase type 5 (PDE5) inhibitor. This therapeutic classification is specifically designed to treat erectile dysfunction by enhancing erectile response to stimulation. It works by blocking the enzyme PDE5, which results in increased levels of cyclic guanosine monophosphate (cGMP) and consequently leads to vasodilation in the corpus cavernosum of the penis. This mechanism improves blood flow and helps achieve and maintain an erection.

The other classifications listed, such as ACE inhibitors, beta-blockers, and antibiotics, pertain to entirely different mechanisms and therapeutic uses. ACE inhibitors are primarily used to manage hypertension and heart failure, beta-blockers are employed for a variety of cardiovascular conditions, and antibiotics are utilized to treat bacterial infections. Therefore, the correct classification for Sildenafil as a PDE5 inhibitor is crucial for its appropriate therapeutic application.