When using Nitroglycerin patches or extended-release capsules, patients should allow for which of the following?

Nitroglycerin patches and extended-release capsules are used to prevent angina attacks by providing a steady release of medication over time. It is crucial for patients using these forms of nitroglycerin to have a drug-free interval of 10 to 12 hours. This interval is important to prevent tolerance, where the body becomes less responsive to the medication if it is used continuously without breaks. By allowing this period where no medication is administered, the efficacy of nitroglycerin is maintained, maximizing its therapeutic benefits and minimizing potential side effects associated with prolonged exposure to nitrates. This practice aligns with standard recommendations for nitrate therapy to ensure the best outcomes for patients managing conditions like angina.