Which adverse drug reaction is most commonly associated with Prazosin?

Prazosin is primarily an alpha-1 adrenergic antagonist used to treat hypertension and symptoms of benign prostatic hyperplasia. The most commonly associated adverse drug reaction with Prazosin is dizziness and postural hypotension. This reaction occurs due to the drug's mechanism of action, which leads to vasodilation and a decrease in peripheral vascular resistance. As blood vessels relax, there can be a significant drop in blood pressure, especially in patients who change positions rapidly, leading to dizziness or lightheadedness upon standing (postural hypotension).

While headache, nausea, and fatigue are potential side effects associated with many medications, they are not as frequently observed in patients taking Prazosin compared to the likelihood of experiencing dizziness and postural hypotension. The understanding of Prazosin's pharmacodynamics highlights the importance of monitoring blood pressure and advising patients about the risks of orthostatic changes, making the dizziness and postural hypotension a central focus when considering its adverse effects.