Which adverse effect is associated with Chlorthalidone?

Chlorthalidone, a thiazide-like diuretic, is primarily used to treat hypertension and edema by promoting diuresis, which is the increased production of urine. One of the major adverse effects associated with this class of drugs, particularly Chlorthalidone, is hypotension. This occurs because the medication decreases blood volume through the excretion of sodium and water, leading to lower blood pressure.

While it is essential to monitor blood pressure when prescribing Chlorthalidone, hypotension can manifest especially in patients who are also taking other antihypertensive agents, are dehydrated, or have conditions that predispose them to low blood pressure. Recognizing hypotension as an adverse effect is critical, as it can lead to symptoms such as dizziness, fainting, or falls, especially in elderly patients or those with multiple comorbidities.

The other options are not typical adverse effects of Chlorthalidone. For example, weight loss is not a commonly expected outcome. Hyperkalemia, which refers to elevated levels of potassium in the blood, is usually more associated with potassium-sparing diuretics, rather than with Chlorthalidone, which can actually cause hypokalemia—low potassium levels.