Which common adverse drug reaction is associated with Valsartan/Sacubitril?

Valsartan/Sacubitril is a combination medication used primarily for the treatment of heart failure with reduced ejection fraction. One of the common adverse drug reactions (ADRs) associated with this medication is hypotension. This is a result of the mechanism by which Valsartan, an angiotensin receptor blocker (ARB), works to reduce blood pressure by blocking the effects of angiotensin II, a hormone that contributes to vasoconstriction. The addition of sacubitril, which inhibits neprilysin (an enzyme that breaks down natriuretic peptides), enhances diuresis and vasodilation, further lowering blood pressure.

Patients receiving Valsartan/Sacubitril may experience a significant drop in blood pressure, especially upon initiation of therapy or with dose adjustments. Careful monitoring of blood pressure is essential to avoid adverse effects related to excessive hypotension, such as dizziness or fainting.

Other potential side effects of this medication can include weight gain, headache, and rash, but these are less common than hypotension in the context of its pharmacological profile. Thus, hypotension stands out as the most relevant and commonly encountered adverse reaction associated with Valsartan/Sacubitril.