Which of the following indicates a contraindication for rosuvastatin?

Rosuvastatin is a medication belonging to the statin class, which is primarily used to lower cholesterol levels and reduce the risk of cardiovascular diseases. Its contraindications are particularly important in populations such as pregnant individuals, as statins are associated with potential risks.

Pregnancy is a known contraindication for the use of rosuvastatin due to the potential harm it can cause to the developing fetus. During the first trimester, the organogenesis phase of fetal development occurs, making the fetus particularly sensitive to teratogenic effects of medications. Statins, including rosuvastatin, have been classified as Category X, indicating that they should not be used during pregnancy because of the evidence of fetal harm. This is why pregnancy in the first trimester specifically represents a contraindication for rosuvastatin.

In contrast, the third trimester does not negate the potential risks associated with statin use, but the emphasis is more on the critical developmental stages that occur in the early months of gestation. It's important to demonstrate awareness of the high risks to the fetus throughout pregnancy and take necessary precautions. However, the categorization of contraindications primarily highlights the risks during the first trimester due to organ formation.

Breastfeeding is generally considered safe for many medications when weighed against