Which of the following is a notable side effect of Ramipril?

Ramipril, an ACE (Angiotensin-Converting Enzyme) inhibitor, is well known for causing a dry cough as a notable side effect. This occurs because ACE inhibitors increase the levels of bradykinin, a peptide that can lead to the stimulation of sensory nerves in the respiratory tract, resulting in a persistent cough. This side effect can be bothersome enough that some patients may need to discontinue the medication.

Other options such as constipation, fluid retention, and weight gain are not commonly associated with Ramipril. In fact, ACE inhibitors like Ramipril are often used to help reduce fluid retention and manage blood pressure, and they typically do not contribute to weight gain or constipation as a primary effect. These distinctions highlight why the dry cough is a significant and well-documented side effect of Ramipril.