Which of the following is a common adverse drug reaction to Furosemide?

Furosemide, a loop diuretic, is commonly associated with hyperuricemia due to its mechanism of action. It works by inhibiting the reabsorption of sodium and chloride in the loop of Henle within the nephron, leading to increased excretion of water, sodium, chloride, magnesium, calcium, and potassium. This increased renal elimination can result in elevated uric acid levels in the blood, as the drug can compete with uric acid for secretion in the renal tubules, ultimately increasing the reabsorption of uric acid and leading to hyperuricemia. This is particularly relevant for patients who may already be predisposed to high uric acid levels or gout, making it a notable adverse effect to monitor for in patients receiving Furosemide therapy.

While nausea, rash, and headache may occur, they are not as closely associated with Furosemide as hyperuricemia is. Understanding the pharmacological effects and the common metabolic consequences helps healthcare providers anticipate and manage potential adverse reactions while treating patients with this diuretic.