Which of the following is a common adverse drug reaction associated with Spironolactone?

Spironolactone is a potassium-sparing diuretic, commonly used for conditions such as heart failure, hypertension, and edema. While patients may experience various side effects from medications, the most common adverse reactions associated with spironolactone do not typically include headache, nausea, or drowsiness.

Instead, more common adverse effects related to its pharmacological action can include hyperkalemia (increased potassium levels), gynecomastia (breast tissue enlargement in males), and menstrual irregularities in females. However, among the given choices, none of them are identified as common adverse reactions linked to spironolactone, making "None" the appropriate selection. This highlights the importance of recognizing specific side effects of medications in clinical practice.