Which of the following is a common adverse drug reaction to Hydrochlorothiazide and Triamterene?

Hydrochlorothiazide and Triamterene are diuretic medications often used together to manage conditions such as hypertension and edema. One of the well-known adverse effects associated with this combination is hypotension, which refers to abnormally low blood pressure. This occurs because both medications promote diuresis, or increased urine production, leading to a reduction in blood volume. When blood volume decreases significantly, it can result in lower blood pressure, potentially leading to symptoms like dizziness or fainting, particularly upon standing.

Hypotension is particularly important to monitor in patients who are elderly, dehydrated, or taking other medications that may further lower blood pressure. While nausea, hyperglycemia, and fatigue can occur with various medications, they are not as directly linked to the action of Hydrochlorothiazide and Triamterene as hypotension is, making it the most relevant adverse drug reaction to consider in this context.