Which of the following is a labeled indication for Apixaban?

Apixaban is an anticoagulant that is primarily indicated for its use in patients with nonvalvular atrial fibrillation to reduce the risk of stroke and systemic embolism. This indication is crucial in patients who have abnormal heart rhythms, as it helps to prevent blood clots that can lead to serious cardiovascular events. The correct answer acknowledges this specific and clinically significant use of Apixaban.

The other options do not accurately reflect labeled indications for Apixaban. Chronic hypertension refers to high blood pressure management, which does not involve anticoagulation. Heart failure management typically focuses on different classes of medications, such as diuretics or ACE inhibitors, rather than direct anticoagulants like Apixaban. Finally, while Apixaban may be used in the context of acute coronary syndrome in some patients as part of a broader treatment plan, it is not specifically indicated for outright management of acute coronary syndrome itself. Therefore, the choice highlighting atrial fibrillation as a labeled indication aligns with the established clinical guidelines and usage of Apixaban in practice.