Which of the following is not a common adverse drug reaction of Rivaroxaban?

Rivaroxaban, an anticoagulant used for preventing and treating blood clots, typically presents certain common adverse drug reactions associated with its mechanism of action. Among these, bleeding is a well-known and significant risk, as the drug works by inhibiting Factor Xa in the coagulation cascade, which naturally increases the likelihood of bleeding events.

On the other hand, nausea, diarrhea, and headache are less commonly associated with Rivaroxaban. While these may occur in some patients, they are not primary concerns and tend to be mild compared to the risk of bleeding associated with the drug's anticoagulant properties. Therefore, among the options provided, bleeding is the concern most inherent to the pharmacological effects of Rivaroxaban, while nausea, diarrhea, and headache, although possible, do not have the same prominence as adverse drug reactions. This makes bleeding the key adverse effect associated with Rivaroxaban, thereby identifying it as the primary complication that patients and healthcare providers watch for in treatment with this medication.