Which of the following medications is most likely to cause drowsiness when taken with Prazosin?

Prazosin is an alpha-1 adrenergic antagonist primarily used to treat hypertension and symptoms of benign prostatic hyperplasia. One of its common side effects is sedation, particularly due to its impact on the central nervous system. When alcohol is consumed alongside Prazosin, it can potentiate these sedative effects, leading to increased drowsiness and impaired coordination. Both Prazosin and alcohol can depress the central nervous system, which can intensify the overall sedative response.

While the other medications listed have their own effects and interactions, they are less likely to cause drowsiness in conjunction with Prazosin. For example, Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) primarily used for pain relief and inflammation without sedative properties. Amoxicillin is an antibiotic that does not typically impact sedation levels. Montelukast, a leukotriene receptor antagonist used mainly for asthma and allergies, also does not have sedative effects. Therefore, alcohol is the most directly implicated in causing enhanced drowsiness when taken with Prazosin.