Which of the following symptoms should prompt a patient on Atorvastatin to notify their prescriber?

Patients taking Atorvastatin should be particularly vigilant about any unexplained muscle tenderness or weakness. This symptom is crucial to report to a prescriber because it may indicate a serious condition known as rhabdomyolysis, a rare but potentially life-threatening side effect of statin medications. Rhabdomyolysis can lead to significant muscle breakdown, resulting in kidney damage or failure if not addressed promptly.

Other symptoms, such as headache, dry mouth, or nausea, while they may be uncomfortable or disruptive, are generally more common and less severe. They do not typically indicate a life-threatening reaction associated with Atorvastatin. Therefore, muscle symptoms are the most significant indicators that should prompt immediate medical consultation. Recognizing and responding to these serious side effects can help ensure patient safety while on statin therapy.