Which side effect is associated with both Lisinopril and Hydrochlorothiazide?

Dizziness is a recognized side effect associated with both Lisinopril and Hydrochlorothiazide. Lisinopril, an ACE inhibitor, can cause a drop in blood pressure when standing up (orthostatic hypotension), which may lead to feelings of lightheadedness or dizziness. Similarly, Hydrochlorothiazide, a thiazide diuretic, can result in volume depletion and electrolyte imbalances, both of which can contribute to dizziness.

Understanding the pharmacological effects of these drugs helps clarify why dizziness is common among patients taking them. The blood pressure-lowering effect of Lisinopril, alongside the diuretic effect of Hydrochlorothiazide, often leads to a decrease in overall fluid volume and blood pressure, increasing the potential for dizziness, especially after standing quickly or during the initiation of therapy.

While nasal congestion, dry mouth, and fatigue may occur due to various mechanisms or as side effects of different medications, they are not specifically associated with both Lisinopril and Hydrochlorothiazide in the way that dizziness is, making it the most appropriate choice in this context.