Which statement is true about the combination of Sulfamethoxazole and Trimethoprim?

The combination of Sulfamethoxazole and Trimethoprim is effective in enhancing antibacterial activity against a wide range of organisms. Sulfamethoxazole is a sulfonamide that interferes with bacterial folic acid synthesis, while Trimethoprim inhibits a later step in the same metabolic pathway. This synergistic action allows for a broader spectrum of activity than either drug alone, making it particularly effective against many Gram-positive and Gram-negative bacteria.

This combination is commonly used in treating various infections, including urinary tract infections and respiratory infections, due to its ability to target a broader range of pathogens with improved efficacy. The enhanced activity arises from the complementary mechanisms of action, resulting in a more potent antimicrobial effect. Hence, the statement about their combined enhanced activity against many bacteria reflects the well-established utility of this drug combination in clinical practice.