Which system does Lisinopril's mechanism of action potentiate?

Lisinopril primarily acts on the renin-angiotensin system, which is crucial for regulating blood pressure and fluid balance. It is an angiotensin-converting enzyme (ACE) inhibitor that works by inhibiting the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. This inhibition leads to a decrease in angiotensin II levels, resulting in vasodilation, reduced secretion of aldosterone, and ultimately, lower blood pressure.

Potentiation of the renin-angiotensin system, through its inhibition, is essential for managing conditions such as hypertension and heart failure. By blocking the effects of angiotensin II, Lisinopril facilitates improved blood flow, reduced workload on the heart, and decreased risk of cardiovascular events.

In contrast, other systems listed do not play a primary role in Lisinopril's mechanism. The sympathetic nervous system is involved in the 'fight or flight' response and influences heart rate and blood pressure but is not directly modified by Lisinopril. Likewise, the kallikrein-kinin system deals with vasodilation and in some contexts can interact with the effects of ACE inhibitors, but it is not the primary target of Lisinop