Within how many hours should treatment for VZV be started after the appearance of rash?

The correct timeframe for initiating treatment for Varicella-Zoster Virus (VZV) is ideally within 24 hours after the appearance of the rash. Early treatment can significantly reduce the severity of the disease, lower the risk of complications, and decrease the duration of symptoms. Antiviral medications, such as acyclovir, are most effective when started early in the course of the infection, typically recognized by the onset of the characteristic vesicular rash.

Starting treatment beyond this 24-hour window may still have some benefits, particularly for individuals with increased risk for severe disease, but the optimal impact is observed when treatment is initiated promptly. Thus, the importance of beginning treatment within this timeframe emphasizes the need for quick medical intervention, especially in high-risk populations like immunocompromised patients or adults, who are more prone to severe complications from VZV.